Will a 1997 s10 motor interchange in a 1995 s10?

If it is the v-6 motor it will kinda "fit"... There are lots problems though. The fuel injection system is different as are the location and number of engine sensors. The 1995 V-6 it technically a 1 year only engine. I own a 1989, 1995 and 1996 s-10's. The 1989 is different due to throttle body injection. The 1995 blew a motor and we finally found a 1994 engine to "FIT" but the timing cover is different, intake manifold is slightly different and the distributor is non-adjustable on the 1995. (computer sets the timing.) We got it to work but lucky for me my son is a Certified Master Technician and he was able to figure out how and where to hook up the sensors on the engine to make it run since they were not the same and located in different places from 1994 - 1995. Again the 1996 motor is still different from the 1995 or we would have tried to find a 1996 - 1998 motor to "fit"... (1996 and newer has a totally different fuel injection system.) You may be able to use the old intake manifold on the newer motor and solve that part of the problem.

The only problem with doing this is that the computer and fuel injection systems changed in 1996. Most of the engines before that had a throttle body and the ones after had individual injectors. Also the throttle body injection system only ran on 13-15 psi fuel pressure and the newer ones (vortec) run on 60+ psi. So you will need to make sure that you have the same systems on them to trade. Other wise you will have to use the intake manifold and injectors from the S10 your planning to drive. as long as they are both the same size of engine. If considering using a V-8 in the S-10, Contact Jags that Run (JTR) enterprises. They have a manual that shows detailed info on how to do the swap.

It should enter change there is just a couple years difference and I don't think they changed the motors to much. It also depends on the size of the motor if there not the same you may have to change the transmission out as well.

if there the same motor.